He defied Alzheimer’s for two decades. Scientists want to know how.

The Washington Post

By Carolyn Y. Johnson

May 15, 2023

Rare resilient patients may help researchers develop new therapies for the devastating disease

When a Colombian man was first evaluated by neurologists at age 67, he was cognitively normal, and neither he nor his family had concerns about his memory. So scientists began to follow his extraordinarycase closely.

The patient — a mechanic who was a husband and father of two — had been born with a particularly sinister gene mutation that should have doomed him to dementia before his 50th birthday.

Instead, his life had been one of remarkable resilience, bucking the script written in his genes. The cognitive impairment that should have started at age 44 stayed at bay for more than two decades. Rather than dying in his early 60s, he retired. He did eventually develop moderate dementia, and he passed away in 2019 at the age of 74.

This man is only the second patient identified with the miraculous ability to defy the devastating Alzheimer’s gene, an international team of scientists report in the journal Nature Medicine. Doctors hope the two known cases will allow researchers to develop new treatments toprotect other people with Alzheimer’s disease, which affects 6.7 million people in the United States.

The researchers sifted through the man’s genome to identify a different mutation that may have helped protect him against the disease. They also used brain scans taken when he was 73 to home in on a key region that appears to have been relatively protected against the tau protein tangles that typically occur in Alzheimer’s patients.

“I think it’s important that we listen to the patients. And I think what the patients are telling us is … there is a pathway for protection,” said Joseph F. Arboleda-Velasquez, an associate scientist at Mass Eye and Ear, a Harvard teaching hospital, and one of the leaders of the study.

“These are very provocative findings, and I do think these cases have something very important to teach us about resilience to disease and the biology” of Alzheimer’s, said Gil Rabinovici, a neurologist at the University of California at San Francisco, who was not involved in the study.

“I think this raises a number of interesting questions. I don’t know that we have the answers.”

A genetic time bomb

For decades, neurologist Francisco Lopera at the University of Antioquia in Medellín, Colombia, has been caring for and following an extended family, many of whose members carry a tragically unlucky mutation in a gene called presenilin 1. The mutation is rare, and its effects are aggressive and predictable.

By their late 20s, people who carry the mutation have brains clogged with the hallmark amyloid plaques that characterize Alzheimer’s disease. By their mid 30s, tangles of a different protein associated with Alzheimer’s, tau, appear.

People carrying this gene begin to experience the first inklings of cognitive problems around age 44, and by 49, they have full-blown dementia. They typically die in their 60s.

In total, scientists have discovered 1,200 people out of an extended family of more than 6,000 carrying this genetic time bomb.

Yakeel T. Quiroz, director of the Familial Dementia Neuroimaging Lab at Massachusetts General Hospital, has worked with Lopera and these patients for 20 years.

“You meet them before they have symptoms, and you see them progress,” Quiroz said. “You get to stay around and see how they become severely demented — and how they die. There’s nothing you can do to stop it.”

But in 2019, researchers discovered a single patient, Aliria Rosa Piedrahita de Villegas, who seemed to have fended off fate.

Her memory didn’t start to decline until she was in her 70s. Scientists discovered a genetic mutation that protected her, nicknamed Christchurch. Although her brain was clogged with the characteristic amyloid plaques of Alzheimer’s, it was relatively free of the tangles of tau that are also associated with the disease.

Scientists marveled at the case but also debated its relevance. This was only one person. Was it an aberration, or a path to follow? What could this one person reveal about how to fight Alzheimer’s in the broader population?

A tangled target for Alzheimer’s drugs

The discovery of a second person with genetic resiliencevalidates the quest but also deepens the mystery.

The man, whose identity is anonymous at his family’s request, doesn’t have the Christchurch gene variant. He appears to have been protected due to a mutation in a different gene called reelin.

What’s more, both patients had brains riddled with amyloid plaques, which have so far been a key target in therapies for Alzheimer’s.

Recently, drugs aimed at clearing amyloid plaques have been approved in the United States — the first beacons of hope in decades. But these drugs are far from a cure. They aim to slow the progression of the disease, but have fostered debate and criticism over whether modest benefits outweigh their risks and costs.

The woman’s lack of tau tangles supported an alternate avenue for therapeutics. When the man traveled to Massachusetts to have his brain scanned at age 73, researchers found that he had both amyloid plaques and tau tangles associated with Alzheimer’s disease. But crucially,tau was relatively limited in hisentorhinal cortex, which is essential for memory.

“The possibility that just by protecting the entorhinal cortex, even if you have a lot of Alzheimer’s pathology elsewhere, you can have that protection? Wouldn’t that be amazing. That’s what’s very tantalizing,” Arboleda-Velasquez said.

Scientists, including those involved in the research, cautioned that the study is far from a definitive explanation of why the man’s memory was protected for years. There could be multiple contributors, rather than a single explanation.

But the possibility that a person could have a high level of protection against decline, even with a brain that is substantially affected by amyloid and tau buildup, is “intriguing” said Inmaculada Cuchillo Ibañez, a neuroscientist at the Institute of Neurosciences at Miguel Hernández University in Alicante, Spain. She has studied the reelin protein in the brains of people with more common forms of Alzheimer’s disease.

“This suggests that this … could be critical in protecting against cognitive impairment,” Cuchillo Ibañez wrote in an email.

The researchers did find an overlap between the two different gene mutations that helped protect these individuals: Bothmutations affect proteins that bind to the same receptors on the surfaces of brain cells. The scientists also found that mice that are genetically predisposed to develop tau tangles in their brains were less likely to do so when they carried the reelin gene mutation found in the man.

Understanding the possible biochemical pathways that produced protection opens up new approaches for drug development, the researchers said.

Quiroz said the man’s family members were excited that something useful had been learned from his case. Patients and researchers are both aware that the disease moves so quickly that discoveries may only benefit future generations. ButLopera said in an email that these exceptional cases point the way forward.

The two cases, he wrote, “have enormous potential to benefit the entire world population with or at risk of Alzheimer’s disease because they are showing a path to prevention and cure.”